2x0w

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Image:2x0w.png

Template:STRUCTURE 2x0w

Contents

STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-DIMETHOXY-2-METHYLBENZOTHIAZOLE

Template:ABSTRACT PUBMED 20142040

About this Structure

2x0w is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29;17(1):46-56. PMID:20142040 doi:10.1016/j.chembiol.2009.12.011
  • Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838

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