1l3p
From Proteopedia
|
CRYSTAL STRUCTURE OF THE FUNCTIONAL DOMAIN OF THE MAJOR GRASS POLLEN ALLERGEN Phl p 5b
Overview
The major allergen Phlp 5b from timothy grass pollen induces allergic, rhinitis and bronchial asthma in millions of allergic patients worldwide., As an important step towards understanding the interactions between the, pollen protein and components of the human immune system, the structure of, the C-terminal key domain of Phlp 5b has been determined at 2.0 A, resolution and refined to an R value of 19.7%. This is the first known, allergen composed entirely of alpha-helices. The protein forms a dimer, stabilized by one intermolecular disulfide bridge. Sequence homology, suggests that at least all group V and group VI grass-pollen allergens, belong to this new class of 'four-helix-bundle allergens'.
About this Structure
1L3P is a Single protein structure of sequence from Phleum pratense with PO4 and MG as ligands. Full crystallographic information is available from OCA.
Reference
Structure of the functional domain of the major grass-pollen allergen Phlp 5b., Rajashankar K, Bufe A, Weber W, Eschenburg S, Lindner B, Betzel C, Acta Crystallogr D Biol Crystallogr. 2002 Jul;58(Pt 7):1175-81. Epub 2002, Jun 20. PMID:12077438
Page seeded by OCA on Tue Nov 20 20:13:30 2007
Categories: Phleum pratense | Single protein | Betzel, Ch. | Bufe, A. | Eschenburg, S. | Lindner, B. | Rajashankar, K.R. | Weber, W. | MG | PO4 | Allergy | Grass pollen allergen | Phl p 5b | Structure
