2oj9

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Image:2oj9.png

Template:STRUCTURE 2oj9

Contents

Structure of IGF-1R kinase domain complexed with a benzimidazole inhibitor

Template:ABSTRACT PUBMED 17317169

Disease

Known disease associated with this structure: Insulin-like growth factor I, resistance to OMIM:[147370]

About this Structure

2OJ9 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Velaparthi U, Wittman M, Liu P, Stoffan K, Zimmermann K, Sang X, Carboni J, Li A, Attar R, Gottardis M, Greer A, Chang CY, Jacobsen BL, Sack JS, Sun Y, Langley DR, Balasubramanian B, Vyas D. Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R). Bioorg Med Chem Lett. 2007 Apr 15;17(8):2317-21. Epub 2007 Feb 4. PMID:17317169 doi:10.1016/j.bmcl.2007.01.102

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