2hqu

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Template:STRUCTURE 2hqu

Contents 1 Human dUTPase in complex with alpha,beta-iminodUTP and magnesium ion 2 About this Structure 3 See Also 4 Reference

Human dUTPase in complex with alpha,beta-iminodUTP and magnesium ion

Template:ABSTRACT PUBMED 17880943

About this Structure

2hqu is a 3 chain structure of Deoxyuridine 5'-triphosphate nucleotidohydrolase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Deoxyuridine 5'-triphosphate nucleotidohydrolase

Reference

• Varga B, Barabas O, Kovari J, Toth J, Hunyadi-Gulyas E, Klement E, Medzihradszky KF, Tolgyesi F, Fidy J, Vertessy BG. Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. FEBS Lett. 2007 Oct 2;581(24):4783-8. Epub 2007 Sep 12. PMID:17880943 doi:10.1016/j.febslet.2007.09.005
• Mol CD, Harris JM, McIntosh EM, Tainer JA. Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits. Structure. 1996 Sep 15;4(9):1077-92. PMID:8805593
• Vertessy BG, Toth J. Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. Acc Chem Res. 2009 Jan 20;42(1):97-106. PMID:18837522 doi:10.1021/ar800114w