3r1g

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Image:3r1g.png

Template:STRUCTURE 3r1g

Contents

Structure Basis of Allosteric Inhibition of BACE1 by an Exosite-Binding Antibody

Template:ABSTRACT PUBMED 21613622

About this Structure

3r1g is a 3 chain structure of Antibody and Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Atwal JK, Chen Y, Chiu C, Mortensen DL, Meilandt WJ, Liu Y, Heise CE, Hoyte K, Luk W, Lu Y, Peng K, Wu P, Rouge L, Zhang Y, Lazarus RA, Scearce-Levie K, Wang W, Wu Y, Tessier-Lavigne M, Watts RJ. A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-{beta} Production in Vivo. Sci Transl Med. 2011 May 25;3(84):84ra43. PMID:21613622 doi:10.1126/scitranslmed.3002254

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