1ony

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Image:1ony.png

Template:STRUCTURE 1ony

Contents

Oxalyl-Aryl-Amino Benzoic Acid inhibitors of PTP1B, compound 17

Template:ABSTRACT PUBMED 12747781

About this Structure

1ony is a 1 chain structure of Tyrosine phosphatase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Liu G, Szczepankiewicz BG, Pei Z, Janowick DA, Xin Z, Hajduk PJ, Abad-Zapatero C, Liang H, Hutchins CW, Fesik SW, Ballaron SJ, Stashko MA, Lubben T, Mika AK, Zinker BA, Trevillyan JM, Jirousek MR. Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. J Med Chem. 2003 May 22;46(11):2093-103. PMID:12747781 doi:http://dx.doi.org/10.1021/jm0205696
  • Wiesmann C, Barr KJ, Kung J, Zhu J, Erlanson DA, Shen W, Fahr BJ, Zhong M, Taylor L, Randal M, McDowell RS, Hansen SK. Allosteric inhibition of protein tyrosine phosphatase 1B. Nat Struct Mol Biol. 2004 Aug;11(8):730-7. Epub 2004 Jul 18. PMID:15258570 doi:10.1038/nsmb803

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