1mk2
From Proteopedia
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SMAD3 SBD complex
Contents |
Overview
Smad3 transduces the signals of TGF-betas, coupling transmembrane receptor, kinase activation to transcriptional control. The membrane-associated, molecule SARA (Smad Anchor for Receptor Activation) recruits Smad3 for, phosphorylation by the receptor kinase. Upon phosphorylation, Smad3, dissociates from SARA and enters the nucleus, in which its transcriptional, activity can be repressed by Ski. Here, we show that SARA and Ski, recognize specifically the monomeric and trimeric forms of Smad3, respectively. Thus, trimerization of Smad3, induced by phosphorylation, simultaneously activates the TGF-beta signal by driving Smad3 dissociation, from SARA and sets up the negative feedback mechanism by Ski. Structural, models of the Smad3/SARA/receptor kinase complex and Smad3/Ski complex, provide insights into the molecular basis of regulation.
Disease
Known diseases associated with this structure: Anderson disease OMIM:[607690], Chylomicron retention disease OMIM:[607690], Chylomicron retention disease with Marinesco-Sjogren syndrome OMIM:[607690], Mowat-Wilson syndrome OMIM:[605802]
About this Structure
1MK2 is a Protein complex structure of sequences from Homo sapiens with ACY as ligand. Full crystallographic information is available from OCA.
Reference
Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control., Qin BY, Lam SS, Correia JJ, Lin K, Genes Dev. 2002 Aug 1;16(15):1950-63. PMID:12154125
Page seeded by OCA on Mon Nov 12 18:12:19 2007
Categories: Homo sapiens | Protein complex | Correia, J.J. | Lam, S.S. | Lin, K. | Qin, B.Y. | ACY | Sara | Sbd | Smad3
