3bvb

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 3bvb

Contents 1 Cystal structure of HIV-1 Active Site Mutant D25N and inhibitor Darunavir 2 About this Structure 3 See Also 4 Reference

Cystal structure of HIV-1 Active Site Mutant D25N and inhibitor Darunavir

Template:ABSTRACT PUBMED 18281688

About this Structure

3bvb is a 2 chain structure of Virus protease with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

See Also

• Virus protease

Reference

• Sayer JM, Liu F, Ishima R, Weber IT, Louis JM. Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease. J Biol Chem. 2008 May 9;283(19):13459-70. Epub 2008 Feb 15. PMID:18281688 doi:10.1074/jbc.M708506200
• Ishima R, Torchia DA, Lynch SM, Gronenborn AM, Louis JM. Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor. J Biol Chem. 2003 Oct 31;278(44):43311-9. Epub 2003 Aug 21. PMID:12933791 doi:http://dx.doi.org/10.1074/jbc.M307549200
• Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:16277992 doi:10.1016/j.jmb.2005.09.095