1mpu
From Proteopedia
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Crystal Structure of the free human NKG2D immunoreceptor
Overview
Engagement of diverse protein ligands (MIC-A/B, ULBP, Rae-1, or H60) by, NKG2D immunoreceptors mediates elimination of tumorigenic or virally, infected cells by natural killer and T cells. Three previous NKG2D-ligand, complex structures show the homodimeric receptor interacting with the, monomeric ligands in similar 2:1 complexes, with an equivalent surface on, each NKG2D monomer binding intimately to a total of six distinct ligand, surfaces. Here, the crystal structure of free human NKG2D and in silico, and in vitro alanine-scanning mutagenesis analyses of the complex, interfaces indicate that NKG2D recognition degeneracy is not explained by, a classical induced-fit mechanism. Rather, the divergent ligands appear to, utilize different strategies to interact with structurally conserved, elements of the consensus NKG2D binding site.
About this Structure
1MPU is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands., McFarland BJ, Kortemme T, Yu SF, Baker D, Strong RK, Structure. 2003 Apr;11(4):411-22. PMID:12679019
Page seeded by OCA on Fri Feb 15 16:25:07 2008
