This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3fcu
From Proteopedia
Contents |
Structure of headpiece of integrin aIIBb3 in open conformation
Template:ABSTRACT PUBMED 19111664
Disease
Known disease associated with this structure: Glanzmann thrombasthenia, type A OMIM:[607759], Thrombocytopenia, neonatal alloimmune OMIM:[607759]
About this Structure
3FCU is a 6 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA. Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Mol Cell. 2008 Dec 26;32(6):849-61. PMID:19111664 doi:10.1016/j.molcel.2008.11.018
Page seeded by OCA on Wed Jan 21 10:49:26 2009
Categories: Homo sapiens | Luo, B H. | Nishida, N. | Springer, T A. | Xiao, T. | Zhang, C. | Zhu, J. | Allostery | Alternative splicing | Cell adhesion | Cell adhesion/blood clotting complex | Cell adhesion/immune system complex | Crystal structure | Disease mutation | Fibrinogen binding | Glycoprotein | Host-virus interaction | Integrin | Membrane | Phosphoprotein | Platelet integrin alphaiibbeta3 | Polymorphism | Receptor | Therapeutic antagonism | Transmembrane
