3d28

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Image:3d28.png

Template:STRUCTURE 3d28

Contents

Crystal structure of hcv ns5b polymerase with a novel benzisothiazole inhibitor

Template:ABSTRACT PUBMED 18554907

About this Structure

3d28 is a 2 chain structure of RNA polymerase with sequence from Viruses. Full crystallographic information is available from OCA.

See Also

Reference

  • Kim SH, Tran MT, Ruebsam F, Xiang AX, Ayida B, McGuire H, Ellis D, Blazel J, Tran CV, Murphy DE, Webber SE, Zhou Y, Shah AM, Tsan M, Showalter RE, Patel R, Gobbi A, LeBrun LA, Bartkowski DM, Nolan TG, Norris DA, Sergeeva MV, Kirkovsky L, Zhao Q, Han Q, Kissinger CR. Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4181-5. Epub 2008 May 24. PMID:18554907 doi:10.1016/j.bmcl.2008.05.083

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