3l3m

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Template:STRUCTURE 3l3m

Contents 1 PARP complexed with A927929 2 About this Structure 3 See Also 4 Reference

PARP complexed with A927929

Template:ABSTRACT PUBMED 20337371

About this Structure

3l3m is a 1 chain structure of Poly (ADP-ribose) polymerase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Poly (ADP-ribose) polymerase

Reference

• Penning TD, Zhu GD, Gong J, Thomas S, Gandhi VB, Liu X, Shi Y, Klinghofer V, Johnson EF, Park CH, Fry EH, Donawho CK, Frost DJ, Buchanan FG, Bukofzer GT, Rodriguez LE, Bontcheva-Diaz V, Bouska JJ, Osterling DJ, Olson AM, Marsh KC, Luo Y, Giranda VL. Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. J Med Chem. 2010 Apr 22;53(8):3142-53. PMID:20337371 doi:10.1021/jm901775y