1h1b

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Image:1h1b.png

Template:STRUCTURE 1h1b

Contents

CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL ELASTASE COMPLEXED WITH AN INHIBITOR (GW475151)

Template:ABSTRACT PUBMED 12190311

About this Structure

1h1b is a 2 chain structure of Elastase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Macdonald SJ, Dowle MD, Harrison LA, Clarke GD, Inglis GG, Johnson MR, Shah P, Smith RA, Amour A, Fleetwood G, Humphreys DC, Molloy CR, Dixon M, Godward RE, Wonacott AJ, Singh OM, Hodgson ST, Hardy GW. Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151). J Med Chem. 2002 Aug 29;45(18):3878-90. PMID:12190311

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