2o2f

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Template:STRUCTURE 2o2f

Contents

Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand

Template:ABSTRACT PUBMED 17256834

About this Structure

2o2f is a 1 chain structure of Bcl-2 with sequence from Homo sapiens. Full experimental information is available from OCA.

See Also

Reference

  • Bruncko M, Oost TK, Belli BA, Ding H, Joseph MK, Kunzer A, Martineau D, McClellan WJ, Mitten M, Ng SC, Nimmer PM, Oltersdorf T, Park CM, Petros AM, Shoemaker AR, Song X, Wang X, Wendt MD, Zhang H, Fesik SW, Rosenberg SH, Elmore SW. Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem. 2007 Feb 22;50(4):641-62. Epub 2007 Jan 26. PMID:17256834 doi:http://dx.doi.org/10.1021/jm061152t

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