1n3n
From Proteopedia
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Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db
Overview
The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock, protein (hsp) 60 is recognized by the murine T-cell receptor UZ-3-4 in, complex with the murine class I major histocompatibility complex molecule, H-2D(b). This T-cell receptor cross-reacts with the H-2D(b)-bound, non-homologous decameric peptide KDIGNIISDA from the murine hsp60, but, does not recognize the nonameric mycobacterial peptide SALQNAASI., Cross-recognition of the KDIGNIISDA/H-2D(b) complex induces autoimmune, pathology in immunodeficient mice. We solved the X-ray crystal structure, of the SALQNAASIA/H-2D(b) complex at 3.0 A resolution, and we modelled the, KDIGNIISDA and SALQNAASI peptides in the H-2D(b) binding site. The, structural analysis of the H-2D(b)-bound hsp60 epitopes offers insight, into T-cell receptor cross-reactivity.
About this Structure
1N3N is a Protein complex structure of sequences from Mus musculus with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db., Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG, FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:12753896
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