1n46

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spinqualitylabelsall models 1n46, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

In this communication, we wish to describe the discovery of a novel series, of 6-azauracil-based thyromimetics that possess up to 100-fold, selectivities for binding and functional activation of the beta(1)-isoform, of the thyroid receptor family. Structure-activity relationship studies on, the 3,5- and 3'-positions provided compounds with enhanced TR beta, affinity and selectivity. Key binding interactions between the 6-azauracil, moiety and the receptor have been determined through of X-ray, crystallographic analysis.

Disease

Known diseases associated with this structure: Thyroid hormone resistance OMIM:[190160], Thyroid hormone resistance, autosomal recessive OMIM:[190160]

About this Structure

1N46 is a Single protein structure of sequence from Homo sapiens with PFA as ligand. Full crystallographic information is available from OCA.

Reference

Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics., Dow RL, Schneider SR, Paight ES, Hank RF, Chiang P, Cornelius P, Lee E, Newsome WP, Swick AG, Spitzer J, Hargrove DM, Patterson TA, Pandit J, Chrunyk BA, LeMotte PK, Danley DE, Rosner MH, Ammirati MJ, Simons SP, Schulte GK, Tate BF, DaSilva-Jardine P, Bioorg Med Chem Lett. 2003 Feb 10;13(3):379-82. PMID:12565933

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