3kn0

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Template:STRUCTURE 3kn0

Contents 1 Structure of BACE bound to SCH708236 2 About this Structure 3 See Also 4 Reference

Structure of BACE bound to SCH708236

Template:ABSTRACT PUBMED 20043700

About this Structure

3kn0 is a 2 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Wang YS, Strickland C, Voigt JH, Kennedy ME, Beyer BM, Senior MM, Smith EM, Nechuta TL, Madison VS, Czarniecki M, McKittrick BA, Stamford AW, Parker EM, Hunter JC, Greenlee WJ, Wyss DF. Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors. J Med Chem. 2009 Dec 31. PMID:20043700 doi:10.1021/jm901472u