1n95
From Proteopedia
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Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine Derivatives
Overview
Inhibitors of farnesyltransferase are effective against a variety of, tumors in mouse models of cancer. Clinical trials to evaluate these agents, in humans are ongoing. In our effort to develop new farnesyltransferase, inhibitors, we have discovered a series of aryl tetrahydropyridines that, incorporate substituted glycine, phenylalanine and histidine residues. The, design, synthesis, SAR and biological properties of these compounds will, be discussed.
About this Structure
1N95 is a Protein complex structure of sequences from Rattus norvegicus with ZN, HFP and FTH as ligands. Full crystallographic information is available from OCA.
Reference
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives., Gwaltney SL 2nd, O'Connor SJ, Nelson LT, Sullivan GM, Imade H, Wang W, Hasvold L, Li Q, Cohen J, Gu WZ, Tahir SK, Bauch J, Marsh K, Ng SC, Frost DJ, Zhang H, Muchmore S, Jakob CG, Stoll V, Hutchins C, Rosenberg SH, Sham HL, Bioorg Med Chem Lett. 2003 Apr 7;13(7):1359-62. PMID:12657282
Page seeded by OCA on Tue Nov 20 22:04:07 2007
