1nfk

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Image:1nfk.jpg

1nfk, resolution 2.300Å

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STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER

Overview

The 2.3-A crystal structure of the transcription factor NK-kappa B p50, homodimer bound to a palindromic kappa B site reveals that the Rel, homology region folds into two distinct domains, similar to those in the, immunoglobulin superfamily. The p50 dimer envelopes an undistorted B-DNA, helix, making specific contacts along the 10-base-pair kappa B recognition, site mainly through loops connecting secondary structure elements in both, domains. The carboxy-terminal domains form a dimerization interface, between beta-sheets using residues that are strongly conserved in the Rel, family.

About this Structure

1NFK is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of NF-kappa B p50 homodimer bound to a kappa B site., Ghosh G, van Duyne G, Ghosh S, Sigler PB, Nature. 1995 Jan 26;373(6512):303-10. PMID:7530332

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