2x0u

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Template:STRUCTURE 2x0u

Contents 1 STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-AMINO SUBSTITUTED BENZOTHIAZOLE SCAFFOLD 2 About this Structure 3 See Also 4 Reference

STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO A 2-AMINO SUBSTITUTED BENZOTHIAZOLE SCAFFOLD

Template:ABSTRACT PUBMED 20142040

About this Structure

2x0u is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• P53

Reference

• Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29;17(1):46-56. PMID:20142040 doi:10.1016/j.chembiol.2009.12.011
• Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838