2zm3

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Image:2zm3.png

Template:STRUCTURE 2zm3

Contents

Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor

Template:ABSTRACT PUBMED 18501599

Disease

Known disease associated with this structure: Insulin-like growth factor I, resistance to OMIM:[147370]

About this Structure

2ZM3 is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mayer SC, Banker AL, Boschelli F, Di L, Johnson M, Kenny CH, Krishnamurthy G, Kutterer K, Moy F, Petusky S, Ravi M, Tkach D, Tsou HR, Xu W. Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3641-5. Epub 2008 Apr 25. PMID:18501599 doi:10.1016/j.bmcl.2008.04.044

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