2ant

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Template:STRUCTURE 2ant

Contents 1 THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE 2 About this Structure 3 See Also 4 Reference

THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE

Template:ABSTRACT PUBMED 9067613

About this Structure

2ant is a 2 chain structure of Antithrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Antithrombin

Reference

• Skinner R, Abrahams JP, Whisstock JC, Lesk AM, Carrell RW, Wardell MR. The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site. J Mol Biol. 1997 Feb 28;266(3):601-9. PMID:9067613 doi:10.1006/jmbi.1996.0798
• Alberdi E, Hyde CC, Becerra SP. Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site. Biochemistry. 1998 Jul 28;37(30):10643-52. PMID:9692954 doi:10.1021/bi9802317
• Whisstock JC, Pike RN, Jin L, Skinner R, Pei XY, Carrell RW, Lesk AM. Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparindagger. J Mol Biol. 2000 Sep 1;301(5):1287-305. PMID:10966821 doi:10.1006/jmbi.2000.3982