1nwm
From Proteopedia
|
GAT domain of human GGA1
Overview
The Golgi-associated, gamma-adaptin homologous, ADP-ribosylation factor, (ARF)-interacting proteins (GGAs) are adaptors that sort receptors from, the trans-Golgi network into the endosomallysosomal pathway. The GGAs and, TOM1 (GAT) domains of the GGAs are responsible for their ARF-dependent, localization. The 2.4-A crystal structure of the GAT domain of human GGA1, reveals a three-helix bundle, with a long N-terminal helical extension, that is not conserved in GAT domains that do not bind ARF. The ARF binding, site is located in the N-terminal extension and is separate from the core, three-helix bundle. An unanticipated structural similarity to the, N-terminal domain of syntaxin 1a was discovered, comprising the entire, three-helix bundle. A conserved binding site on helices 2 and 3 of the GAT, domain three-helix bundle is predicted to interact with, coiled-coil-containing proteins. We propose that the GAT domain is, descended from the same ancestor as the syntaxin 1a N-terminal domain, and, that both protein families share a common function in binding coiled-coil, domain proteins.
About this Structure
1NWM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor., Suer S, Misra S, Saidi LF, Hurley JH, Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4451-6. Epub 2003 Mar 31. PMID:12668765
Page seeded by OCA on Mon Nov 12 18:26:42 2007
