2zjk

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Template:STRUCTURE 2zjk

Contents 1 Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide 2 About this Structure 3 See Also 4 Reference

Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide

Template:ABSTRACT PUBMED 019284778

About this Structure

2zjk is a 3 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Beta secretase

Reference

• Yang W, Fucini RV, Fahr BT, Randal M, Lind KE, Lam MB, Lu W, Lu Y, Cary DR, Romanowski MJ, Colussi D, Pietrak B, Allison TJ, Munshi SK, Penny DM, Pham P, Sun J, Thomas AE, Wilkinson JM, Jacobs JW, McDowell RS, Ballinger MD. Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering. Biochemistry. 2009 Jun 2;48(21):4488-96. PMID:19284778 doi:10.1021/bi900017q