1o9m
From Proteopedia
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THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.
Overview
The ribosome is an important target for aminoglycoside antibiotics;, however, the clinical effectiveness of aminoglycosides has diminished due, to bacterial resistance mechanisms. Here we report the X-ray structure of, a novel synthetic aminoglycoside bound to the A site of the ribosome, its, target for manifestation of activity. The structure validates the in, silico design paradigms for the antibiotic and reveals the molecular, interactions made by this novel antibiotic in prokaryotes.
About this Structure
1O9M is a Single protein structure of sequence from [1] with , , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography., Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S, J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:12643685
Page seeded by OCA on Sun Feb 3 09:55:16 2008
Categories: Single protein | Murray, J.B. | Russell, R. | 42B | BDG | P24 | PA2 | A-site | Rna-antibiotic interactions
