1pcf

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Image:1pcf.gif

1pcf, resolution 1.74Å

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HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN

Overview

The crystal structure of human replication and transcription cofactor, PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels, running in opposite directions to each other. This arrangement suggests a, role in establishment or maintenance of melted DNA at promoters or origins, of replication.

About this Structure

1PCF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site., Brandsen J, Werten S, van der Vliet PC, Meisterernst M, Kroon J, Gros P, Nat Struct Biol. 1997 Nov;4(11):900-3. PMID:9360603

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