1pdr
From Proteopedia
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CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN FROM THE HUMAN HOMOLOG OF DISCS LARGE PROTEIN
Overview
PDZ domains (also known as DHR domains or GLGF repeats) are approximately, 90-residue repeats found in a number of proteins implicated in ion-channel, and receptor clustering, and the linking of receptors to effector enzymes., PDZ domains are protein-recognition modules; some recognize proteins, containing the consensus carboxy-terminal tripeptide motif S/TXV with high, specificity. Other PDZ domains form homotypic dimers: the PDZ domain of, the neuronal enzyme nitric oxide synthase binds to the PDZ domain of, PSD-95, an interaction that has been implicated in its synaptic, association. Here we report the crystal structure of the third PDZ domain, of the human homologue of the Drosophila discs-large tumour-suppressor, gene product, DlgA. It consists of a five-stranded antiparallel, beta-barrel flanked by three alpha-helices. A groove runs over the surface, of the domain, ending in a conserved hydrophobic pocket and a buried, arginine; we suggest that this is the binding site for the C-terminal, peptide.
About this Structure
1PDR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of a PDZ domain., Morais Cabral JH, Petosa C, Sutcliffe MJ, Raza S, Byron O, Poy F, Marfatia SM, Chishti AH, Liddington RC, Nature. 1996 Aug 15;382(6592):649-52. PMID:8757139
Page seeded by OCA on Fri Feb 15 16:39:56 2008
