1pm4
From Proteopedia
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Crystal structure of Yersinia pseudotuberculosis-derived mitogen (YPM)
Overview
Superantigens are a class of microbial proteins with the ability to, excessively activate T cells by binding to the T cell receptor. The, staphylococcal and streptococcal superantigens are closely related in, structure and possess an N-terminal domain that resembles an OB fold and a, C-terminal domain similar to a beta-grasp fold. Yersinia, pseudotuberculosis produces superantigens, YPMa, YPMb, and YPMc, which, have no significant amino acid similarity to other proteins. We have, determined the crystal and solution structures of YPMa, which show that, the protein has a jelly-roll fold. The closest structural neighbors to, YPMa are viral capsid proteins and members of the tumor necrosis factor, superfamily. In the crystal structure, YPMa packs as a trimer, another, feature shared with viral capsid proteins and TNF superfamily proteins., However, in solution YPMa behaves as a monomer, and any functional, relevance of the trimer observed in the crystals is yet to be established.
About this Structure
1PM4 is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.
Reference
Crystal and solution structures of a superantigen from Yersinia pseudotuberculosis reveal a jelly-roll fold., Donadini R, Liew CW, Kwan AH, Mackay JP, Fields BA, Structure. 2004 Jan;12(1):145-56. PMID:14725774
Page seeded by OCA on Sun Nov 25 02:41:05 2007
