1pn5
From Proteopedia
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NMR structure of the NALP1 Pyrin domain (PYD)
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Overview
Signaling in apoptosis and inflammation is often mediated by proteins of, the death domain superfamily in the Fas/FADD/Caspase-8 or the, Apaf-1/Caspase-9 pathways. This superfamily currently comprises the death, domain (DD), death effector domain (DED), caspase recruitment domain, (CARD), and pyrin domain (PYD) subfamilies. The PYD subfamily is most, abundant, but three-dimensional structures are only available for the, subfamilies DD, DED, and CARD, which have an antiparallel arrangement of, six alpha helices as common fold. This paper presents the NMR structure of, PYD of NALP1, a protein that is involved in the innate immune response and, is a component of the inflammasome. The structure of NALP1 PYD differs, from all other known death domain superfamily structures in that the third, alpha helix is replaced by a flexibly disordered loop. This unique feature, appears to relate to the molecular basis of familial Mediterranean fever, (FMF), a genetic disease caused by single-point mutations.
Disease
Known diseases associated with this structure: Cramps, familial, potassium-aggravated OMIM:[603967], Hyperkalemic periodic paralysis OMIM:[603967], Hypokalemic periodic paralysis OMIM:[603967], Myasthenic syndrome OMIM:[603967], Myotonia congenita, atypical, acetazolamide-responsive OMIM:[603967], Paramyotonia congenita OMIM:[603967], Vitiligo-associated multiple autoimmune disease susceptibility 1 OMIM:[606636]
About this Structure
1PN5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain., Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grutter MG, Wuthrich K, Structure. 2003 Oct;11(10):1199-205. PMID:14527388
Page seeded by OCA on Mon Nov 12 18:45:40 2007
