Sandbox Reserved 461

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Revision as of 19:38, 7 November 2012 by Christian A. Crevar (Talk | contribs)
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This Sandbox is Reserved from 13/03/2012, through 01/06/2012 for use in the course "Proteins and Molecular Mechanisms" taught by Robert B. Rose at the North Carolina State University, Raleigh, NC USA. This reservation includes Sandbox Reserved 451 through Sandbox Reserved 500.
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Contents

Glutamate Dehydrogenase

Glutamate Dehydrogenase

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Overview 

    Fuck this shit

Structure

Glutamate Dehydrogenase is a hexamer that is comprised of two trimer subunits. These two subunits are stacked and composed of three domains. The top of each domain contains a "NAD-binding domain" that has the conserved nucleotide-binding motif. A larger helix-loop-helix structure rises above this and is referred to as an "antenna." This antenna contains approximately 50 amino acids and plays a major role in regulation of the enzyme. (1)

Mechanism

L-Glutamate + NADP + H2O <--2-Oxoglutarate + NADPH + NH4+ + H+

Glutamate + NAD(P)+ + H2O <--> 2-Oxoglutarate + NH4 + + NAD(P)H.


(1) http://www.sciencedirect.com.prox.lib.ncsu.edu/science/article/pii/S0968000408001898 (2) http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1974.tb03565.x/pdf (3) http://onlinelibrary.wiley.com/doi/10.1002/prot.340120109/pdf (4) http://www.sciencedirect.com/science/article/pii/S0969212699801014

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