From Proteopedia
proteopedia linkproteopedia link Human Thrombin Inhibitor
Thrombin is a serine protease that cleaves fibrinogen to allow fibrin to form stringy networks that trap red blood cells to form clots. Thrombin when made by the body is tethered to blood vessels so that it cannot cause clots and spread throughout the body causing strokes and heart attacks. Additionally, thrombin is only activated for a few seconds
It is in the class of serine protease because the
Introduction
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This is the of thrombin
[1]
Inhibitor 65
The
(p1, p2) [2]
References
- ↑ Steinmetzer T, Baum B, Biela A, Klebe G, Nowak G, Bucha E. Beyond Heparinization: Design of Highly Potent Thrombin Inhibitors Suitable for Surface Coupling. ChemMedChem. 2012 Aug 20. doi: 10.1002/cmdc.201200292. PMID:22907907 doi:10.1002/cmdc.201200292
- ↑ M. R. Wiley, N. Y. Chirgadze, D. K. Clawson, T. J. Craft, D. S. GiffordMoore, N. D. Jones, J. L. Olkowski, L. C. Weir, G. F. Smith, Bioorg. Med. Chem. Lett. 1996, 6, 2387. http://www.sciencedirect.com/science/article/pii/0960894X96004428
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