1qa6
From Proteopedia
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CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX
Overview
The structure of a highly conserved complex between a 58-nucleotide domain, of large subunit ribosomal RNA and the RNA-binding domain of ribosomal, protein L11 has been solved at 2.8 angstrom resolution. It reveals a, precisely folded RNA structure that is stabilized by extensive tertiary, contacts and contains an unusually large core of stacked bases. A bulge, loop base from one hairpin of the RNA is intercalated into the distorted, major groove of another helix; the protein locks this tertiary interaction, into place by binding to the intercalated base from the minor groove side., This direct interaction with a key ribosomal RNA tertiary interaction, suggests that part of the role of L11 is to stabilize an unusual RNA fold, within the ribosome.
About this Structure
1QA6 is a Single protein structure of sequence from Geobacillus stearothermophilus with MG and OS as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of a conserved ribosomal protein-RNA complex., Conn GL, Draper DE, Lattman EE, Gittis AG, Science. 1999 May 14;284(5417):1171-4. PMID:10325228
Page seeded by OCA on Wed Nov 21 00:31:10 2007
