2uue

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Template:STRUCTURE 2uue

Contents 1 REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors 2 About this Structure 3 See Also 4 Reference

REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors

About this Structure

2uue is a 6 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2c5t. Full crystallographic information is available from OCA.

See Also

• Cell Division Protein Kinase 2
• Cyclin

Reference

• Andrews MJ, Kontopidis G, McInnes C, Plater A, Innes L, Cowan A, Jewsbury P, Fischer PM. REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors. Chembiochem. 2006 Dec;7(12):1909-15. PMID:17051658 doi:10.1002/cbic.200600189
• Kontopidis G, McInnes C, Pandalaneni SR, McNae I, Gibson D, Mezna M, Thomas M, Wood G, Wang S, Walkinshaw MD, Fischer PM. Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design. Chem Biol. 2006 Feb;13(2):201-11. PMID:16492568 doi:http://dx.doi.org/10.1016/j.chembiol.2005.11.011