Cooperative Stabilization of Zn2+: DNA Complexes Through Netropsin Binding in the Minor Groove of FdU-Substituted DNA
Supratim Ghosh, Freddie R. Salsbury Jr., David A. Horita and William H. Gmeiner [1]
Molecular Tour
We find that a hairpin DNA that incorporates the modified base FdU when complexed with the small molecule netropsin and zinc displays increased cytotoxicity towards PC3 prostate cancer cells relatives to their components or separate complexes. In order to investigate the origin of this cytotoxicity, we used NMR spectroscopy, circular dichroism, and semi-empirical quantum mechanical calculations to study and model the new structural motif formed by this complex. In this complex, the whereas .
