1byf

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Image:1byf.gif

1byf, resolution 2.0Å

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STRUCTURE OF TC14; A C-TYPE LECTIN FROM THE TUNICATE POLYANDROCARPA MISAKIENSIS

Overview

C-type lectins are calcium-dependent carbohydrate-recognising proteins., Isothermal titration calorimetry of the C-type Polyandrocarpa lectin, (TC14) from the tunicate Polyandrocarpa misakiensis revealed the presence, of a single calcium atom per monomer with a dissociation constant of 2.6, microM, and confirmed the specificity of TC14 for D -galactose and related, monosaccharides. We have determined the 2.2 A X-ray crystal structure of, Polyandrocarpa lectin complexed with D -galactose. Analytical, ultracentrifugation revealed that TC14 behaves as a dimer in solution., This is reflected by the presence of two molecules in the asymmetric unit, with the dimeric interface formed by antiparallel pairing of the two, N-terminal beta-strands and hydrophobic interactions. TC14 adopts a, typical ... [(full description)]

About this Structure

1BYF is a [Single protein] structure of sequence from [Polyandrocarpa misakiensis] with CA, ZN, ACT and GOL as [ligands]. Structure known Active Sites: CAA and CAB. Full crystallographic information is available from [OCA].

Reference

The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D -galactose., Poget SF, Legge GB, Proctor MR, Butler PJ, Bycroft M, Williams RL, J Mol Biol. 1999 Jul 23;290(4):867-79. PMID:10398588

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