1qoy
From Proteopedia
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E.COLI HEMOLYSIN E (HLYE, CLYA, SHEA)
Overview
Hemolysin E (HlyE) is a novel pore-forming toxin of Escherichia coli, Salmonella typhi, and Shigella flexneri. Here we report the X-ray crystal, structure of the water-soluble form of E. coli HlyE at 2.0 A resolution, and the visualization of the lipid-associated form of the toxin in, projection at low resolution by electron microscopy. The crystal structure, reveals HlyE to be the first member of a new family of toxin structures, consisting of an elaborated helical bundle some 100 A long. The electron, micrographs show how HlyE oligomerizes in the presence of lipid to form, transmembrane pores. Taken together, the data from these two structural, techniques allow us to propose a simple model for the structure of the, pore and for membrane interaction.
About this Structure
1QOY is a Single protein structure of sequence from Escherichia coli with SO4 as ligand. Full crystallographic information is available from OCA.
Reference
E. coli hemolysin E (HlyE, ClyA, SheA): X-ray crystal structure of the toxin and observation of membrane pores by electron microscopy., Wallace AJ, Stillman TJ, Atkins A, Jamieson SJ, Bullough PA, Green J, Artymiuk PJ, Cell. 2000 Jan 21;100(2):265-76. PMID:10660049
Page seeded by OCA on Wed Nov 21 00:51:21 2007
