SandboxPKA

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ABL1, also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia.


Structure

c-Abl tyrosine kinase

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Catalitic domain

<\Catalitic domainSection load='3DY7' size='350' side='right' caption='ATP binding domain'>

Aquí se sigue

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