1rlb
From Proteopedia
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RETINOL BINDING PROTEIN COMPLEXED WITH TRANSTHYRETIN
Contents |
Overview
The three-dimensional structure of the complex formed by two plasma, proteins, transthyretin and retinol-binding protein, was determined from, x-ray diffraction data to a nominal resolution of 3.1 angstroms. One, tetramer of transthyretin was bound to two molecules of retinol-binding, protein. The two retinol-binding protein molecules established molecular, interactions with the same transthyretin dimer, and each also made, contacts with one of the other two monomers. Thus, the other two potential, binding sites in a transthyretin tetramer were blocked. The amino acid, residues of the retinol-binding protein that were involved in the contacts, were close to the retinol-binding site.
Disease
Known diseases associated with this structure: Amyloid neuropathy, familial, several allelic types OMIM:[176300], Amyloidosis, senile systemic OMIM:[176300], Carpal tunnel syndrome, familial OMIM:[176300], Dystransthyretinemic hyperthyroxinemia OMIM:[176300], Retinol binding protein, deficiency of OMIM:[180250]
About this Structure
1RLB is a Protein complex structure of sequences from Gallus gallus and Homo sapiens with REA as ligand. Full crystallographic information is available from OCA.
Reference
Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein., Monaco HL, Rizzi M, Coda A, Science. 1995 May 19;268(5213):1039-41. PMID:7754382
Page seeded by OCA on Mon Nov 12 19:05:15 2007
