1rob

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Image:1rob.gif

1rob, resolution 1.6Å

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STRUCTURE OF THE CRYSTALLINE COMPLEX OF CYTIDYLIC ACID (2'-CMP) WITH RIBONUCLEASE AT 1.6 ANGSTROMS RESOLUTION

Overview

The X-ray structure of the inhibitor complex of bovine ribonuclease A with, cytidylic acid (2'-CMP) has been determined at 1.6 A resolution and, refined by restrained least squares to R = 0.17 for 11 945 reflections., Binding of the inhibitor molecule to the protein is confirmed to be in the, productive mode associated with enzyme activity. A study of conserved, solvent sites amongst high-resolution structures in the same crystal form, reveals a stabilizing water cluster between the N and C termini.

About this Structure

1ROB is a Single protein structure of sequence from Bos taurus with C2P as ligand. Active as Pancreatic ribonuclease, with EC number 3.1.27.5 Full crystallographic information is available from OCA.

Reference

Structure of the crystalline complex of cytidylic acid (2'-CMP) with ribonuclease at 1.6 A resolution. Conservation of solvent sites in RNase-A high-resolution structures., Lisgarten JN, Gupta V, Maes D, Wyns L, Zegers I, Palmer RA, Dealwis CG, Aguilar CF, Hemmings AM, Acta Crystallogr D Biol Crystallogr. 1993 Nov 1;49(Pt 6):541-7. PMID:15299491

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