1sdb

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PORCINE DESB1-2 DESPENTAPEPTIDE(B26-B30) INSULIN

Overview

Insulin has a concentration of 10(-8)-10(-11) M in the blood which ensures, that it circulates and exerts its physiological functions in vivo as a, monomer. The crystal structure of monomeric porcine desB1-B2, despentapeptide (B26-B30) insulin (DesB1-2 DPI) with M(r) = 4934 Da has, been determined at 1.65 A resolution using the molecular replacement, method. A structural comparison between DesB1-2 DPI and 2Zn insulin, reveals that the conformation of DesB1-2 DPI is more similar to molecule I, than molecule II of 2Zn insulin. The remarkable conformational difference, between B25-Phe in DesB1-2 DPI and B25-Phe in despentapeptide (B26-B30), insulin (DPI) indicates that the residue B25-Phe possesses great, flexibility and mobility.

About this Structure

1SDB is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Structure of monomeric porcine DesB1-B2 despentapeptide (B26-B30) insulin at 1.65 A resolution., Diao JS, Wan ZL, Chang WR, Liang DC, Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):507-12. PMID:15299880

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