1sei
From Proteopedia
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STRUCTURE OF 30S RIBOSOMAL PROTEIN S8
Overview
BACKGROUND. Prokaryotic ribosomal protein S8 is an important RNA-binding, protein that occupies a central position within the small ribosomal, subunit. It interacts extensively with 16S rRNA and is crucial for the, correct folding of the central domain of the rRNA. S8 also controls the, synthesis of several ribosomal proteins by binding to mRNA. It binds, specifically to very similar sites in the two RNA molecules. RESULTS. S8, is divided into two tightly associated domains and contains three regions, that are proposed to interact with other ribosomal components: two, potential RNA-binding sites, and a hydrophobic patch that may interact, with a complementary hydrophobic region of S5. The N-terminal domain fold, is found in several proteins including two that bind double-stranded DNA., CONCLUSIONS. These multiple RNA-binding sites are consistent with the role, of S8 in organizing the central domain and agree with the latest models of, the 16S RNA which show that the S8 location coincides with a region of, complicated nucleic-acid structure. The presence in a wide variety of, proteins of a region homologous to the N-terminal domain supports the idea, that ribosomal proteins must represent some of the earliest protein, molecules.
About this Structure
1SEI is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
Reference
Structural evidence for specific S8-RNA and S8-protein interactions within the 30S ribosomal subunit: ribosomal protein S8 from Bacillus stearothermophilus at 1.9 A resolution., Davies C, Ramakrishnan V, White SW, Structure. 1996 Sep 15;4(9):1093-104. PMID:8805594
Page seeded by OCA on Wed Nov 21 02:19:12 2007
