1sjm

From Proteopedia

Revision as of 00:18, 21 November 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search

1sjm, resolution 1.40Å

Drag the structure with the mouse to rotate

Nitrite bound copper containing nitrite reductase

Overview

A copper-nitrosyl intermediate forms during the catalytic cycle of nitrite, reductase, the enzyme that mediates the committed step in bacterial, denitrification. The crystal structure of a type 2 copper-nitrosyl complex, of nitrite reductase reveals an unprecedented side-on binding mode in, which the nitrogen and oxygen atoms are nearly equidistant from the copper, cofactor. Comparison of this structure with a refined nitrite-bound, crystal structure explains how coordination can change between, copper-oxygen and copper-nitrogen during catalysis. The side-on, copper-nitrosyl in nitrite reductase expands the possibilities for nitric, oxide interactions in copper proteins such as superoxide dismutase and, prions.

About this Structure

1SJM is a Single protein structure of sequence from Alcaligenes faecalis with CU, NO2, ACT and TRS as ligands. Active as Nitrite reductase (NO-forming), with EC number 1.7.2.1 Full crystallographic information is available from OCA.

Reference

Side-on copper-nitrosyl coordination by nitrite reductase., Tocheva EI, Rosell FI, Mauk AG, Murphy ME, Science. 2004 May 7;304(5672):867-70. PMID:15131305

Page seeded by OCA on Wed Nov 21 02:25:31 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools