1pl0

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Image:1pl0.png

Template:STRUCTURE 1pl0

Contents

Crystal structure of human ATIC in complex with folate-based inhibitor, BW2315U89UC

Template:ABSTRACT PUBMED 14966129

Disease

Known disease associated with this structure: AICA-ribosiduria due to ATIC deficiency OMIM:[601731]

About this Structure

1PL0 is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:14966129 doi:10.1074/jbc.M313691200

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