1svb

From Proteopedia

Revision as of 00:35, 21 November 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:1svb.gif

1svb, resolution 1.9Å

Drag the structure with the mouse to rotate

ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS

Overview

The crystallographically determined structure of a soluble fragment from, the major envelope protein of a flavivirus reveals an unusual, architecture. The flat, elongated dimer extends in a direction that would, be parallel to the viral membrane. Residues that influence binding of, monoclonal antibodies lie on the outward-facing surface of the protein., The clustering of mutations that affect virulence in various flaviviruses, indicates a possible receptor binding site and, together with other, mutational and biochemical data, suggests a picture for the, fusion-activating, conformational change triggered by low pH.

About this Structure

1SVB is a Single protein structure of sequence from Tick-borne encephalitis virus with NAG as ligand. Full crystallographic information is available from OCA.

Reference

The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:7753193

Page seeded by OCA on Wed Nov 21 02:42:25 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1svb"
Personal tools