1svz
From Proteopedia
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Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease
Overview
The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the, activity of both HIV-1 and HIV-2 proteases with inhibition constants in, the low nanomolar range. The antibody cross-reacts with peptides derived, from the N-terminal region of both proteases. The crystal structure of the, recombinant single-chain Fv fragment of 1696 complexed with an N-terminal, peptide from the HIV-2 protease has been determined at 1.88A resolution., Interactions of the peptide with scFv1696 are compared with the previously, reported structure of scFv1696 in complex with the corresponding peptide, from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV, proteases is discussed.
About this Structure
1SVZ is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide., Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA, J Struct Biol. 2005 Mar;149(3):332-7. PMID:15721587
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