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Template:STRUCTURE 1wbj

Tryptophan synthase (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide.

Contents 1 3D structures of tryptophan synthase 2 TrpS binary complex 3 TrpS ternary complex with PLP and inhibitor 4 TrpS ternary complex with PLP and IGP derivatives 5 TrpS ternary complex with PLP and G3P derivatives 6 TrpS quaternary complex

3D structures of tryptophan synthase

1x1q - TtTrpS β subunit – Thermus thermophilus
2dh6 - EcTrpS β subunit]] - Escherichia coli
2o2e, 2o2j - TrpS β subunit – Mycobacterium tuberculosis

TrpS binary complex

2dh5 - EcTrpS β subunit + PLP
1ttp, 1ttq, 1bks, 2wsy, 1kfk - StTrpS α + β + PLP – Salmonella typhimurium
1a5a, 1k8x - StTrpS α (mutant) + β + PLP
1k7x, 2j9z - StTrpS α + β (mutant) + PLP
2tys - StTrpS α (mutant) + β (mutant) + Trp derivative
1kfe - StTrpS α (mutant) + β + pyridoxal-serine-monophsphate
1kfj - StTrpS α + β + pyridoxal-serine-monophsphate
2j9y - StTrpS α + β (mutant) + enoic acid derivative
3pr2 - StTrpS α + β + inhibitor

TrpS ternary complex with PLP and inhibitor

1a50, 1cw2, 1c9d, 1cx9, 1c8v, 1c29, 2cle, 2clh, 2cli, 2clk, 2cll, 2clm, 2clo, 2clf - StTrpS α + β + inhibitor + PLP
1fuy - StTrpS α + β (mutant) + inhibitor + PLP

TrpS ternary complex with PLP and IGP derivatives

1a5b, 1kfb - StTrpS α (mutant) + β + IGP + PLP
1k8z - StTrpS α + β (mutant) + IGP derivative + PLP
1kfc - StTrpS α (mutant) + β + IGP derivative + PLP
1k3u, 1k7e, 1k7f - StTrpS α + β + IGP derivative + PLP
1qoq, 2rh9, 2rhg - StTrpS α + β + IGP + PLP
1qop - StTrpS α + β + IGP analog + PLP
2trs, 1beu - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + IGP analog

TrpS ternary complex with PLP and G3P derivatives

1wbj - StTrpS α + β + G3P + PLP
2j9x - StTrpS α + β + G3P + acrylic acid derivative
1k8y - StTrpS α + β (mutant) + G3P derivative + PLP
1tjp - StTrpS α + β + G3P derivative + PLP
2tsy - StTrpS α (mutant) + β (mutant) + pyridoxal-serine-monophsphate + G3P

1ubs - StTrpS α (mutant) + β (mutant) + serine + PLP

TrpS quaternary complex

1a5s - StTrpS α + β + serine + inhibitor + PLP
3cep - StTrpS α + β + G3P + indoline + PLP