1tez

From Proteopedia

Revision as of 08:02, 3 February 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:1tez.gif

1tez, resolution 1.80Å

Drag the structure with the mouse to rotate

COMPLEX BETWEEN DNA AND THE DNA PHOTOLYASE FROM ANACYSTIS NIDULANS

Overview

DNA photolyases use light energy to repair DNA that comprises, ultraviolet-induced lesions such as the cis-syn cyclobutane pyrimidine, dimers (CPDs). Here we report the crystal structure of a DNA photolyase, bound to duplex DNA that is bent by 50 degrees and comprises a synthetic, CPD lesion. This CPD lesion is flipped into the active site and split, there into two thymines by synchrotron radiation at 100 K. Although, photolyases catalyze blue light-driven CPD cleavage only above 200 K, this, structure apparently mimics a structural substate during light-driven DNA, repair in which back-flipping of the thymines into duplex DNA has not yet, taken place.

About this Structure

1TEZ is a Single protein structure of sequence from Synechococcus sp. with , and as ligands. Active as Deoxyribodipyrimidine photo-lyase, with EC number 4.1.99.3 Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Crystal structure of a photolyase bound to a CPD-like DNA lesion after in situ repair., Mees A, Klar T, Gnau P, Hennecke U, Eker AP, Carell T, Essen LO, Science. 2004 Dec 3;306(5702):1789-93. PMID:15576622

Page seeded by OCA on Sun Feb 3 10:02:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tez"
Personal tools