1tgh
From Proteopedia
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TATA BINDING PROTEIN (TBP)/DNA COMPLEX
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Overview
The crystal structure of a complex of human TATA-binding protein with, TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses, from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight, into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a, particularly large minor groove ligand. This point of view provides, explanations for: (1) why T.A base-pairs are required rather than C.G; (2), why an alternation of T and A bases is needed; (3) how TBP recognizes the, upstream and downstream ends of the TATA box in order to bind properly;, and (4) why the second half of the TATA box can be more variable than the, first.
Disease
Known diseases associated with this structure: Huntington disease-like-4 OMIM:[600075], Parkinson disease OMIM:[600075], Spinocerebellar ataxia 17 OMIM:[600075]
About this Structure
1TGH is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1TGH with [TATA-Binding Protein]. Full crystallographic information is available from OCA.
Reference
How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291
Page seeded by OCA on Mon Nov 12 19:24:37 2007
