This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1tzd
From Proteopedia
|
CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE
Overview
Soluble inositol polyphosphates are ubiquitous second messengers in, eukaryotes, and their levels are regulated by an array of specialized, kinases. The structure of an archetypal member of this class, inositol, 1,4,5-trisphosphate 3-kinase (IP3K), has been determined at 2.2 angstroms, resolution in complex with magnesium and adenosine diphosphate. IP3K, contains a catalytic domain that is a variant of the protein kinase, superfamily, and a novel four-helix substrate binding domain. The two, domains are in an open conformation with respect to each other, suggesting, that substrate recognition and catalysis by IP3K involves a dynamic, conformational cycle. The unique helical domain of IP3K blocks access to, the active site by membrane-bound phosphoinositides, explaining the, structural basis for soluble inositol polyphosphate specificity.
About this Structure
1TZD is a Single protein structure of sequence from Rattus norvegicus with MG and ADP as ligands. Active as Inositol-trisphosphate 3-kinase, with EC number 2.7.1.127 Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase., Miller GJ, Hurley JH, Mol Cell. 2004 Sep 10;15(5):703-11. PMID:15350215
Page seeded by OCA on Wed Nov 21 03:43:14 2007
