1ua2
From Proteopedia
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Crystal Structure of Human CDK7
Overview
CDK7, a member of the cyclin-dependent protein kinase family, regulates, the activities of other CDKs through phosphorylation on their activation, segment and hence contributes to control of the eukaryotic cell cycle., CDK7 also assists in the regulation of transcription as part of the, transcription factor TFIIH complex. For maximum activity and stability, CDK7 requires phosphorylation, association with cyclin H, and association, with a third protein, MAT1. We have determined the crystal structure of, human CDK7 in complex with ATP at 3 A resolution. The kinase is in the, inactive conformation, similar to that observed for inactive CDK2. The, activation segment is phosphorylated at Thr170 and is in a defined, conformation that differs from that in phospho-CDK2 and, phospho-CDK2/cyclin A. The functional properties of the enzyme against, CDK2 and CTD as substrates are characterized through kinase assays., Experiments confirm that CDK7 is not a substrate for kinase-associated, phosphatase.
About this Structure
1UA2 is a Single protein structure of sequence from Homo sapiens with ATP as ligand. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
The crystal structure of human CDK7 and its protein recognition properties., Lolli G, Lowe ED, Brown NR, Johnson LN, Structure. 2004 Nov;12(11):2067-79. PMID:15530371
Page seeded by OCA on Mon Nov 12 19:32:57 2007
